The NHGRI intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications to support a network of genomic-enabled learning health systems (gLHS). These health systems will identify and improve approaches for clinical integration of genomic information in a virtuous cycle of implementation, assessment, refinement, and re-implementation. Specifically, this initiative would: 1) support 4-6 established or emerging gLHS clinical sites to share their genomic medicine implementation practices and identify those most suitable for cross-network implementation; 2) use these practices to conduct 2-4 network-wide pilot implementation projects and evaluate their impact; and 3) develop and refine successful gLHS implementation strategies as resources that can be broadly shared and adopted, including in resource-limited settings. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects, and to allow potential applicants with relevant expertise and insights to consider applying for this new NOFO. The NOFO is expected to be published in late summer 2023 with an expected application due date in fall 2023. This NOFO will utilize the U01 activity code; clinical trial is required. Details of the planned NOFO are provided below.