As part of the NIHsHelping to End Addiction Long-term (HEAL) Initiative, theEunice Kennedy ShriverNational Institute of Child Health and Human Development and participating NIH Institutes and Centers (ICs)intend to publish a Notice of Funding Opportunity (NOFO) to support research that aligns with one of the research goals of the NIH HEAL Initiative tosupport new clinical trial programs and the expansion of existing programs to evaluate innovative therapies for pain management.The HEAL KIDS (Knowledge, Innovation and Discovery Studies) Paininitiativewill be comprised of interrelated programs addressing critical needs in pediatric pain research. This Notice of Intent to Publish announces plans to support the Acute Pain Clinical Trials (APCT) program, focusing on research to improve the assessment, management, and treatment of acute pain in pediatric patients in various health care settings through innovative multi-site clinical trials while integrating relevant behavioral and social influences and contexts on pain experience. NICHD intends to utilize a cooperative agreement activity code (U01) for this NOFO. The HEAL KIDS Pain NOFO is anticipated to be published in Summer 2023 with an expected application due date in Fall 2023. Anticipated details of the planned APCT Program are provided below.