This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. TheNIH INCLUDE Project seeks to improve health and quality-of-life for individuals with Down syndrome.The National Institutes of Health, Office of the Director, with other NIH Institutes and Centers (ICs) (NICHD, NHLBI, NIA, NIDCD, NIMH etc.), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for a Down Syndrome Clinical Cohort Coordinating Center (DS-4C). The DS-4C will be responsible for overall project coordination and outreach, support development of new cohorts of people with Down syndrome, and curate the metadata from the new cohorts. A companion NOFO ( NOT-OD-23-134 ) will support the coordinating center. A related NOFO ( NOT-OD-23-136 ) will support a federated biobanking system for the INCLUDE Project. The DS-4C will be a cooperative program committed to support the Down syndrome cohort development program. The DS-4C will provide overall management and oversight for the DS cohort development program, including coordination and communication across all subsections and cores of the program; most importantly, it will lead the effort to outreach to a broader DS community to increase Diversity, Equity, Inclusion and Accessibility (DEIA) within the DS cohort. The DS-4C is expected to work closely with the INCLUDE data repository maintained by theINCLUDE Data Coordinating Center (DCC).