The California Initiative to Advance Precision Medicine (CIAPM) will award up to $9 million total across three to five independent research teams ($1.8 to $3 million per team) over a three-year project term to further understanding about the prevention, diagnosis, and treatment of depression.; The principles of precision medicine call for the modern application of scientific data and clinical practice toward the individualization of prevention, diagnosis, measurement, and treatment of disease and wellbeing. This funding opportunity aims to drive innovation in applying a precision medicine approach to improve clinical outcomes for patients with depression, particularly as a path to reduce health inequities. To ensure the RFP is responsive to community needs, CIAPM hosted a Request for Information and held listening sessions throughout California. California-based research teams must be co-led by at least one non-profit academic research institution and at least one non-profit community-based organization, patient advocacy group, community clinic, or public or tribal entity that provides support to people with or at risk for depression. A key component of these projects is authentic community partnerships with patients and other stakeholders who have a connection to, expertise in, or lived experience related to depression from project conception to project completion and beyond. By the full proposal stage, projects must also include at least one private sector collaborator who contributes in-kind, financial, or other resources to the project. The private sector collaborator should not be a PI and CIAPM funds may not be allocated to support salaries of private sector collaborators. Letters of Intent (LOI) are required, nonbinding, and not scored during the selection process, but must be received by the noted deadline. CIAPM encourages applicants to begin drafting the concept proposals as soon as possible and not necessarily wait until after LOI submission. Key Dates Release of the Notice of Funding Intent | 01/31/2023 Request for Information & Listening Sessions | July-August 2023 Announcement of the RFP | 09/22/2023 Due: Letters of Intent to Submit a Proposal | 10/30/2023 by 12:00 p.m. (Noon) Due: Concept Proposals | 12/1/2023 by 12:00 p.m. (Noon) Notification of Finalists | January 2024 Due: Full Proposals (for Finalists only) | 02/15/2024 by 12:00 p.m. (Noon) Awardees Announced | March 2024 Anticipated Project Start | June 2024 Duration of Projects | 36 months All times listed are in Pacific Time.