With this solicitation, the National Science Foundation's (NSF) Directorate for Computer and Information Science and Engineering (CISE) is continuing its support of research expansion for Minority-Serving Institutions (MSIs). The goal of the CISE-MSI program is to broaden participation by increasing the number of CISE-funded research projects from MSIs and to develop research capacity toward successful submissions to core CISE programs. MSIs are central to inclusive excellence: they foster innovation, cultivate current and future undergraduate and graduate computer and information science and engineering talent, and bolster long-term U.S. competitiveness. For the purposes of this solicitation, MSIs include Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions (HSIs), and Tribal College Universities (TCUs).