Down Syndrome Cohort Research Sites (DS-CRS) for the Down Syndrome Cohort Study Program (DS-CDP) across the lifespan for the INCLUDE Project (U01 Clinical Trial Not Allowed)
HHS-NIH11
Status:
Active
October 19, 2023
Posted:
Deadline:
December 15, 2023
Funding
Program:
Award Floor:
Ceiling:
300000
Match Required?
No
Eligibility
All
States:
Entity Types:
State governments, County governments, City or township governments, Special district governments, Independent school districts, Public & State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities, Native American tribal organizations, Nonprofits (with 501(c)(3) status), Nonprofits (without 501(c)(3) status)
The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This Notice of Funding Opportunity (NOFO) invites applicants to participate in a new INCLUDE Project Down Syndrome Cohort Development Program (DS-CDP) as Cohort Research Sites (DS-CRS). The purpose of this program is to recruit participants with Down syndrome across the lifespan; collect biospecimens; assemble phenotypic data, images, and omics for deep phenotyping; and make the data readily available to the scientific community. Research sites will participate in all aspects of planning and conducting a common protocol, as well as interpretation and translation of results. This NOFO runs in parallel with a companion NOFO (RFA-OD-24-005) that will solicit applications for the Clinical Cohort Coordinating Center (DS-4C) to provide overall coordination of the DS-CDP. A related NOFO (RFA-OD-24-004) will support a Federated Biobanking Resource to store and distribute biospecimens collected by the Cohort Research Sites. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.