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Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R01 Clinical Trial required)




July 19, 2023



March 19, 2025



Award Floor:


Match Required?





Entity Types:

State governments, County governments, City or township governments, Special district governments, Independent school districts, Public & State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities, Native American tribal organizations, Nonprofits (with 501(c)(3) status), Nonprofits (without 501(c)(3) status)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.




Source Type:


The purpose of this FOA is to support the testing of enhanced models of care that optimally integrate HIV, addiction, and primary care services. The purpose of this notice of funding opportunity (NOFO) is to address research gaps in understanding how to improve health outcomes among persons who are at heightened risk for HIV or living with HIV, Hepatitis, and substance use in the US, and to inform novel strategies for integrating primary care, HIV, Hepatitis, and substance use disorder (SUD) prevention and treatment services. Research is sought that will leverage existing resources available to public health researchers to develop and test new methods and models for implementing prevention and treatment services to improve care for at risk individuals. The NOFO will support research that promotes scalable strategies of integrated care and services designed to improve health outcomes related to HIV, Hepatitis B and C (optional) and SUD. Research applications must incorporate HIV/AIDS and SUD outcomes; the HIV/AIDS outcomes should address the HIV prevention and care continuum (i.e., care engagement, antiretroviral adherence, viral suppression), the SUD outcomes should incorporate utilization of screening, prevention services, and referral to pharmacotherapies as appropriate (e.g., all three FDA-approved medications for opioid use disorders). The inclusion of Hepatitis B and/or Hepatitis C in integrated care and services research to improve outcomes in applications is optional. Should Hepatitis be an area of inclusion in proposed research, the outcomes of interest include Hepatitis B and C screening, Hepatitis B vaccination, and/or Hepatitis C treatment.

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