The purpose of the Centers for Disease Control and Prevention National Center for Injury Prevention and Control (NCIPC) Mentored Research Scientist Development Award (K01) is to provide support for an intensive, supervised/mentored career development experience in substance use and/or overdose prevention research leading to research independence. NCIPC supports K01 grants to help ensure the availability of an adequate number of trained scientists to address critical public health research questions to prevent polydrug use and overdose.This funding would support research that aim to better understand and identify risk and protective factors related to any drug use/overdose (e.g., opioids including fentanyl and stimulants, etc.), substance use disorders (SUD), and stigma (e.g., how do certain factors impact stigma). Research can focus the examination of potential moderators or mediators between the relationship between risk and protective factors and drug use and outcomes. Research should be conducted among persons experiencing a disproportionate burden of substance use disorders and overdose, which may include but are not limited, to those people in certain socio-demographic groups (e.g. non-English speaking populations, tribal populations, rural communities, racial/ethnic minority groups, sexual and gender minority groups), people experiencing certain social determinants of health (e.g., reduced economic stability; limited educational attainment, access or quality; limited healthcare access or quality including those who have been historically underserved or are uninsured; limited access to substance use treatment; limited health literacy; those in geographically underserved areas), people experiencing certain social or physical health conditions or experiences (e.g., homelessness, a mental health condition, chronic pain, incarceration or recent release from incarceration, a disability, adverse childhood experiences, a history of suicidal ideation or suicide attempt, a history of substance use disorders and/or overdose).