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Notice of Intent to Publish a Funding Opportunity Announcement for Pre-Cancer Atlas (PCA) Research Centers (U01 Clinical Trial Not Allowed)

HHS-NIH11

Status:

Forecasted

September 25, 2023

Posted:

Deadline: 

December 5, 2023

Funding

7000000

Program:

Award Floor:

Ceiling:

800000

Match Required?

No

Eligibility

All

States:

Entity Types:

State governments, Public & State controlled institutions of higher education, Nonprofits (with 501(c)(3) status), Private institutions of higher education, For profit organizations other than small businesses, Small businesses

The National Cancer Institute (NCI) intends to promote a renewed initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for Pre-Cancer Atlas (PCA) Research Centers, one of the three scientific components of the Human Tumor Atlas Network (HTAN) (NCI Human Tumor Atlas Network). HTAN is a collaborative research initiative and a community resource generating program that is tasked with generating spatial atlases of cancer transitions for a diverse set of precancers and advanced cancers that build upon the current set of public HTAN atlases. HTAN research will span across pivotal points in tumor evolution that include progression from premalignancy to malignancy, primary tumor to metastasis, locoregional tumor recurrence, and response and resistance to treatment. These atlases will enable the development of new classifiers and risk prediction tools, identification of potential targets for preventive interceptions, enhancement of diagnostic and treatment strategies for advanced cancers, and generation of compelling hypotheses to facilitate future research on underlying biological mechanisms. It is imperative that the HTAN atlases are clinically useful for the diverse populations in the United States and the construction process must be mindful of this important aspect. The NOFO will utilize the U01 (Research Project - Cooperative Agreements; Clinical Trial Not Allowed) activity code. Each PCA Research Center will construct one 3-D precancer atlas that comprehensively characterizes a pre-malignant lesion with an explicit focus on understanding the transition from a precancerous lesion to malignancy. The atlas efforts must leverage and expand upon the current HTAN resources and infrastructure and focus on creating spatial atlases at single-cell resolution that are driven by specific topics in cancer biology. Research Centers will collaborate with other PCA and HTA Research Centers and the HTAN Data Coordinating Center (DCC). Research Centers will work with the DCC to make the data and analytical tools available to the research community. This Notice is being provided to allow potential applicants sufficient time to develop a responsive PCA application. The NOFO is expected to be published in September 2023 with an anticipated application due date in December 2023. Details of the planned pre-application webinar will be announced in the Guide after publication of the NOFO.

Contact

Email:

Phone:

Source Type:

Federal

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