The National Institute of Mental Health intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for an Early Psychosis Intervention Network (EPINET) National Data Coordinating Center (ENDCC). The ENDCC will develop infrastructure to facilitate large-scale, practice-oriented research across clinics offering evidence-based Coordinated Specialty Care (CSC) to persons experiencing a first episode of psychosis. This NOFO focuses on research tools and resources directed at (1) optimizing the EPINET Core Assessment Battery (CAB) to support learning health care studies within and across CSC research networks; (2) adapting and implementing the CAB for use in publicly funded CSC programs that aspire to measurement-based care; (3) optimizing the informatics infrastructure and pipelines necessary to gather, store, and upload de-identified, person-level data collected across participating EPINET research networks to the NIMH Data Archive (NDA); and (4) assembling individual network datasets into a national repository of early psychosis clinical features, interventions, and treatment outcomes to be shared with qualified investigators via the NDA. In addition, the ENDCC will provide operational and technical support to the EPINET Research Consortium to promote sharing of methods among research networks. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in Fall 2023 with an expected application due date in Spring 2024 This NOFO will utilize the U24 activity code. Details of the planned NOFO are provided below.