The Directorate for Engineering (ENG), Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET), the Division of Civil, Mechanical and Manufacturing Innovation (CMMI), and the Division of Electrical, Communications and Cyber Systems (ECCS) of the National Science Foundation and the Engineering, ICT and Manufacturing the Future Themes of the UK Engineering and Physical Sciences Research Council (EPSRC) are pleased to announce the ENG-EPSRC Lead Agency Opportunity. The goal of thisopportunity is to reduce some of the barriers that researchers currently encounter when working internationally. The ENG-EPSRC Lead AgencyOpportunity will allow US and UK researchers to submit a single collaborative proposal that will undergo a single review process. Proposals will be accepted for collaborative research in areas at the intersection of CBET, CMMI, and/or ECCS with the EPSRC Engineering, ICT and/or Manufacturing the Future Themes. Proposers choose either NSF or EPSRC to serve as the lead agency to review their proposal. The non-lead agency will honor the rigorof the review process and the decision of the lead agency. For research teams that would like EPSRC to act as lead agency, please see the instructions at:https://epsrc.ukri.org/about/partner/international/agreements/nsf. Proposers should review the CBET, CMMI, and ECCS Program Descriptions for research supported through these divisions and the EPSRC website for further information on what areas of research are eligible for support through this activity. Proposals are expected to adhere to typical proposal budgets and durations for the relevantNSF programs and EPSRC Themes from which funding is sought.