The Agency for International Development (USAID) is pleased to issue a pre-solicitation notification. Please note that interested parties are not required to do anything in response to this pre-solicitation notice. USAID will only accept responses on the due date indicated on the forthcoming Notice of Funding Opportunity (NOFO). The NOFO will be published on the Grants.gov website, and no applications are requested at this time. Please hold all questions for information as they will not be responded to until the actual Request for Application is announced to the public in the coming weeks. This notice in no way obligates USAID to release the NOFO or make an award. Issuance of a NOFO will be subject to internal USAID approvals and the availability of funds. Description USAID/Guinea Sierra Leone anticipates awarding a five-year Cooperative Agreement for the Guinea Local Health System Strengthening (GLHSS) activity. The activitys goal is to contribute to sustainable improvements in the health status of Guineans. The GLHSS will contribute to achieving the following four intermediate results (IRs): IR1: Provision of Quality Mother and Child Health, Family Planning/Reproductive Health and Malaria Services Assured IR2: Health-Enhancing Social Norms Established IR3: Democratic Norms and Processes Strengthened IR4: Cross-Cutting: Use of Strategic Information for Decision-Making Increased The Mission anticipates publishing an announcement seeking applications from eligible and qualified entities following a multi-tiered review process. Potential applicants will first submit a concept paper. After reviewing these submissions, a determination will be made on the best concept papers. Only the accepted concept papers will be invited to submit full applications, reviewed using a more specific merit review criterion. To be eligible for an award, interested parties must have complete registration and valid Dun and Bradstreet Universal Numbering System (DUNS) Number and System for Award Management (SAM) when responding to this NOFO.