The purpose of this notice of funding opportunity is to leverage existing capability and capacity of state public health laboratories to conduct high-quality biomonitoring science and assess human exposure to environmental chemicals within their jurisdictions, specifically focusing on investigations for populations disproportionately affected by exposure to harmful chemicals. Improved exposure assessment will enable states to reduce or eliminate exposure to certain environmental chemicals in at-risk population groups and assess the effectiveness of interventions to reduce harmful exposures. Applicants may propose biomonitoring activities based on one or both of the following strategies to complete during a 3-year funding cycle. 1. Targeted investigations with a clear community of focus, 2. State-wide population surveillance with an emphasis on a community disproportionately affected by exposure or minority groups. Recipient activities will include biomonitoring to assess exposures of concern, enhancement of laboratory capability/expertise, coordination/collaboration with partners to improve exposure investigations, and reporting of findings to key audiences.