GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed)

The GREGoRi Data Coordination and Outreach Center is a forecasted funding opportunity issued by the National Institutes of Health (NIH), specifically under the National Human Genome Research Institute (NHGRI). The funding is part of the renewed Genomics Research to Elucidate the Genetics of Rare Disease (GREGoR) program, now known as GREGoRi: Innovation. This program aims to drive innovation in the diagnosis of rare diseases by transforming the tools, molecular technologies, and analytical approaches used to identify causal genes and variants. This funding opportunity will support the establishment of the GREGoRi Data Coordination and Outreach Center through a cooperative agreement. The center will function as the primary coordinating body within the GREGoRi program, responsible for managing and disseminating data, metadata, computational tools, and protocols developed by the program to the broader research community. It will serve as the hub for both data management and community outreach efforts to ensure transparency, accessibility, and collaboration. Eligible applicants for this funding opportunity include a broad spectrum of entities such as state and county governments, independent school districts, small businesses, for-profit organizations other than small businesses, nonprofit organizations with 501(c)(3) status (excluding institutions of higher education), public and state-controlled institutions of higher education, private institutions of higher education, Native American tribal governments and organizations, and public housing authorities. These entities are encouraged to form collaborations to develop competitive and comprehensive proposals. The funding instrument will be a U01 cooperative agreement, with no cost-sharing or matching requirement. The estimated total program funding is $2,000,000, though specific award floor and ceiling amounts are not yet disclosed. Only one award is anticipated under this announcement. The opportunity is currently in forecast status, allowing potential applicants time to prepare collaborative and responsive proposals. The estimated post date for the official Notice of Funding Opportunity (NOFO) is September 5, 2025, with the application due date projected for November 4, 2025. The estimated award and project start dates are both July 6, 2026. Interested applicants are encouraged to begin preparations now. The grant will utilize the U01 activity code and does not permit clinical trials. For additional information or questions, contact Lisa H. Chadwick at lisa.chadwick@nih.gov or by phone at 301-435-7275.