Notice of Intent to Publish a Funding Opportunity Announcement for Liver Cirrhosis Network: Clinical Research Centers (U01 Clinical Trial Required)

The National Institutes of Health (NIH), under the U.S. Department of Health and Human Services, has announced its intent to publish a Funding Opportunity Announcement (FOA) for the Liver Cirrhosis Network: Clinical Research Centers. This upcoming funding opportunity, to be issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), seeks to support research focused on liver cirrhosis through the U01 cooperative agreement mechanism, which involves substantial NIH scientific and programmatic involvement. The primary objective of this FOA is to continue and complete two ongoing clinical studies within the Liver Cirrhosis Network: the Longitudinal Cohort Study and the RESCU study (Rosuvastatin Efficacy and Safety for Cirrhosis in the United States). Both studies aim to improve understanding and treatment of liver cirrhosis, a progressive condition associated with significant morbidity and mortality. The renewal of the limited competition NOFO RFA-DK-20-003 intends to finish enrollment and continue collaborative research efforts within these studies. Research activities will include data analyses, dissemination of findings, and ancillary analyses, all coordinated with the Liver Cirrhosis Network’s Scientific and Data Coordination Center. The program emphasizes collaborative investigations, particularly those integrating translational science expertise. Interested investigators are encouraged to begin forming research partnerships and designing responsive projects in anticipation of the FOA’s release. Eligible applicants for this opportunity include a wide range of organizations such as city or township governments, county governments, state governments, special district governments, independent school districts, higher education institutions (both public and private), public housing authorities, nonprofits (with or without 501(c)(3) status), small businesses, and Native American tribal entities. No cost-sharing or matching funds are required for application. While this is currently a forecasted opportunity, the estimated post date for the FOA is July 11, 2025, with an expected application due date of August 15, 2025. Awards are anticipated to be made by July 1, 2026, which is also the expected start date for funded projects. The total estimated program funding is $3,302,147, with individual awards capped at $330,214. Approximately ten awards are expected to be distributed under this announcement. For additional information or inquiries regarding this grant opportunity, applicants may contact Dr. Edward Doo at the National Institute of Diabetes and Digestive and Kidney Diseases via phone at 301-451-4524 or by email at dooe@niddk.nih.gov.