Notice of Intent to Publish a Funding Opportunity Announcement for Liver Cirrhosis Network: Scientific and Data Coordination Center (U24 Clinical Trial Optional)

The National Institutes of Health (NIH), through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), has announced a forthcoming Notice of Funding Opportunity (NOFO) for the Liver Cirrhosis Network: Scientific and Data Coordination Center. This opportunity is being shared in advance to allow potential applicants sufficient time to establish collaborations and design responsive proposals. The formal NOFO is expected to be posted by July 11, 2025. The purpose of the grant is to support the ongoing work of the Liver Cirrhosis Network, specifically focusing on completing enrollment for two major studies: the Longitudinal Cohort Study and the RESCU clinical trial. The RESCU trial is a randomized, placebo-controlled Phase 2 study assessing the efficacy and safety of rosuvastatin in patients with liver cirrhosis in the United States. This funding opportunity represents a limited competition renewal of RFA-DK-20-004 and will use the U24 cooperative agreement mechanism. The Scientific and Data Coordination Center funded through this NOFO will provide critical support functions, including clinical study management, technical and biostatistical analysis, dissemination of findings, and execution of ancillary studies. Collaboration is a central focus, particularly for those in translational sciences and liver disease research. Interested investigators are encouraged to start preparations for application even though formal applications are not yet being accepted. Eligible applicants for this grant include a broad range of entities such as independent school districts, for-profit organizations (excluding small businesses), small businesses, public and private higher education institutions, nonprofit organizations (with or without 501(c)(3) status), public housing authorities, Native American tribal entities, and various levels of government including city, county, and state. The estimated due date for applications is August 15, 2025, with an estimated award and project start date of July 1, 2026. No cost sharing or matching is required. The total available funding for this opportunity is projected at $1,835,051, with only one award anticipated. The main contact for this opportunity is Dr. Edward Doo, who can be reached at dooe@niddk.nih.gov or by phone at 301-451-4524.