BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain

The National Institutes of Health (NIH), led by the National Institute on Drug Abuse (NIDA) and supported by other participating NIH Institutes and Centers, is planning to publish a Notice of Funding Opportunity (NOFO) under the BRAIN Initiative. This upcoming grant, titled "BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain," aims to support innovative research that enhances the understanding of dynamic brain circuits through the development of computational tools. These tools, encompassing theories, models, and analytical methods, are intended to aid the scientific community in understanding neural circuit mechanisms and their functional implications. The primary goal of this program is to foster the creation and dissemination of advanced computational resources that can analyze brain data at the resolution of neurons and firing rates or finer. Emphasis will be placed on applications that develop interpretable, mechanistic, and predictive models of neural dynamics and function. Projects should focus on building and distributing tools that are not only innovative but also widely usable by the broader neuroscience research community. This funding opportunity falls under the discretionary category and uses the R01 activity code, signaling a traditional research project grant. The total program funding is projected to be six million dollars, though specific figures for individual award ceilings and floors have not been published. The initiative does not require cost sharing or matching contributions from applicants. Eligibility for this grant is broad, encompassing a wide range of applicants including for-profit organizations (other than small businesses), small businesses, state governments, county governments, public housing authorities, independent school districts, public and private institutions of higher education, nonprofits with 501(c)(3) status, and Native American tribal governments and organizations. This inclusive approach aims to encourage a diverse set of applicants to bring innovative perspectives to this computational neuroscience challenge. The opportunity is currently in the forecast stage, with the official funding announcement expected to be posted by November 5, 2025. Applications will be due by February 5, 2026, with awards anticipated by December 1, 2026. This timeline gives researchers ample lead time to prepare competitive and collaborative proposals. Potential applicants seeking further information or clarification are encouraged to contact Jessica Mollick, PhD, at the National Institute on Drug Abuse, who can be reached at 301-827-2949 or via email at jessica.mollick@nih.gov.