Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)

The National Institutes of Health (NIH), through the Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP), is forecasting the release of a Notice of Funding Opportunity (NOFO) to support resource-related research projects. This initiative aims to foster the development, characterization, and improvement of research models that are used to study human health and diseases. The scope also includes the development of biology-based new approach methodologies (NAMs) and enhancement of access to information derived from such models. The overarching objective of this funding opportunity is to promote resources that are broadly applicable across two or more NIH Institutes or Centers and address diseases or biological processes that affect multiple organ systems. By doing so, the initiative aligns with ORIP’s NIH-wide mission and programs, supporting a wide range of scientific disciplines. Applications must demonstrate both the need for the proposed resources and their potential impact on the research community. Funding will be provided through the R24 activity code, which supports research projects aimed at enhancing the capability of resources to serve biomedical research. Projects may involve the creation of new model resources, improvement of existing ones, or the development of NAMs. Research-focused applications are permissible if they are expected to generate tools or resources with broad biomedical utility. Eligible applicants include public and state-controlled institutions of higher education, nonprofits with 501(c)(3) status, private institutions of higher education, Native American tribal organizations, small businesses, county and state governments, for-profit organizations, and federally recognized Native American tribal governments. Applications must include clear plans for demonstrating resource need, accessibility, impact tracking, and validation of proposed models or tools. The estimated post date for the NOFO is September 26, 2025, with applications due by January 25, 2026. Awards are expected to be announced by October 1, 2026, with project start dates commencing December 1, 2026. Approximately six awards will be granted, with an estimated total program funding of five million dollars. For more detailed information or questions, applicants can contact Sige Zou, PhD, at the Office of Research Infrastructure Programs via phone at 301-435-0749 or by email at [email protected].