Optimizing Treatment Strategies for Adult Attention-Deficit Hyperactivity Disorder (ADHD) (R01 Clinical Trial Required)

The National Institutes of Health (NIH), under the U.S. Department of Health and Human Services, intends to release a Notice of Funding Opportunity (NOFO) focused on improving treatment strategies for adults diagnosed with Attention-Deficit Hyperactivity Disorder (ADHD). This opportunity is managed through the National Institute of Mental Health (NIMH) and utilizes the R01 activity code, which requires clinical trials. It is categorized as a discretionary grant under the health funding activity sector. The purpose of this funding opportunity is to support the development and evaluation of evidence-based treatment modalities for adult ADHD that extend beyond the use of stimulant medications. Funded projects may explore the use of nonstimulant medications, psychosocial interventions, device-based treatments, or a combination thereof. These strategies are intended for cases where stimulant monotherapy is inadequate, intolerable, or otherwise unsuitable. Applicants are expected to consider the management of co-occurring conditions, which are commonly present in individuals with adult ADHD. Although applications are not yet being accepted, this forecasted announcement allows prospective applicants ample time to build collaborative teams and formulate project proposals. Eligible applicants include a wide range of organizations such as private and public higher education institutions, nonprofits (with and without 501(c)(3) status), tribal governments and organizations, for-profit organizations other than small businesses, small businesses, public housing authorities, and various governmental bodies. The anticipated release date for the funding opportunity announcement is August 15, 2025, with applications due by October 15, 2025. The award date and project start date are both scheduled for July 1, 2026. A total of approximately $3,000,000 in funding is expected to be made available, with an estimated four awards to be distributed under this program. There is no cost-sharing or matching requirement for applicants. Applicants and interested parties may direct their inquiries to the grant contact email: NIMHinitiatives@mail.nih.gov. Further updates will be provided on the official grants.gov portal once the NOFO is officially released.