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Federal for Small businesses Grants

Explore 142 grant opportunities

Notice of Intent to Publish a Funding Opportunity Announcement for Investigational New Drug (IND)-enabling and Early-Stage Development of Medications to Treat Alcohol Use disorder and Alcohol-Associated Organ Damage (R43/R44 Clinical Trial Optional)
Contact for amount
US Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Apr 5, 2025

Date Added

Nov 26, 2024

This funding opportunity is designed to support small businesses in developing new medications for treating alcohol use disorder and related organ damage, helping them advance their therapeutic candidates toward FDA approval.

Health
Small businesses
Notice of Intent to Publish a Funding Opportunity Announcement for Investigational New Drug (IND)-enabling and Early-Stage Development of Medications to Treat Alcohol Use disorder and Alcohol-Associated Organ Damage (R41/R42 Clinical Trial Optional)
Contact for amount
US Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Apr 5, 2025

Date Added

Nov 26, 2024

This funding opportunity is designed to support small businesses in developing innovative medications for treating alcohol use disorder and related organ damage, helping them advance their drug candidates toward FDA approval.

Health
Small businesses
Realize Energy-rich Compound Opportunities Valorizing Extraction from Refuse waters (SBIR/STTR)
$4,000,000
US Department of Energy (Advanced Research Projects Agency Energy )
Federal

Application Deadline

Dec 31, 2024

Date Added

Nov 22, 2024

This funding opportunity provides financial support to small businesses developing innovative technologies to recover valuable energy materials from wastewater, promoting U.S. energy security and environmental sustainability.

Opportunity Zone Benefits
Small businesses
Medical Devices for Pediatric Population Affected by Substance Use and Addiction (R43 - Clinical Trials Optional)
$400,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 26, 2025

Date Added

Nov 22, 2024

This funding opportunity supports small businesses in developing innovative medical devices specifically designed to help children and adolescents struggling with substance use and addiction.

Education
Small businesses
Medical Devices for Pediatric Population Affected by Substance Use and Addiction (R41 - Clinical Trials Optional)
$400,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 26, 2025

Date Added

Nov 22, 2024

This funding opportunity provides financial support for small businesses to develop innovative medical devices specifically designed to help children and young adults affected by substance use and addiction.

Education
Small businesses
NHLBI SBIR Phase IIB Small Market Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 Clinical Trial Optional)
$2,333,333
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 26, 2026257 days left

Date Added

Nov 20, 2024

This funding opportunity supports small businesses developing innovative technologies for rare diseases and pediatric populations, helping them bridge the gap between research and commercialization.

Health
Small businesses
NHLBI SBIR Phase IIB Bridge Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 Clinical Trial Optional)
$5,833,333
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 26, 2026257 days left

Date Added

Nov 20, 2024

This grant provides funding to small U.S.-based businesses developing innovative technologies for heart, lung, blood, and sleep disorders, helping them bridge the gap between research and market readiness.

Health
Small businesses
FY 2025 Phase II Release 1
$1,600,000
US Department of Energy (Office of Science)
Federal

Application Deadline

Dec 3, 2024

Date Added

Nov 19, 2024

This funding opportunity provides financial support to small businesses engaged in innovative research and development projects that have the potential for commercialization and significant societal impact.

Science and Technology
Small businesses
Small Business Innovation Research (SBIR) program, Phase I
$100,000
US Department of Health & Human Services (Administration for Community Living)
Federal

Application Deadline

Dec 16, 2024

Date Added

Nov 19, 2024

This funding opportunity supports small businesses in developing innovative projects that improve the lives of individuals with disabilities, focusing on community living, health, and employment accessibility.

Science and Technology
Small businesses
Alumni Engagement Innovation Fund 2025 - Brazil
$35,000
US Department of State (U.S. Mission to Brazil)
Federal

Application Deadline

Jan 10, 2025

Date Added

Nov 19, 2024

This funding opportunity supports alumni of U.S. government-sponsored exchange programs in Brazil to develop community projects that promote democracy, human rights, economic partnerships, and environmental protection, while emphasizing diversity and inclusion.

Other
Small businesses
NOAA Small Business Innovation Research (SBIR) Program- FY25 Phase I
$190,000
US Department of Commerce (DOC NOAA - ERA Production)
Federal

Application Deadline

Jan 15, 2025

Date Added

Nov 18, 2024

This grant provides funding for small businesses to develop innovative technologies that support NOAA's mission in areas like climate change, coastal resilience, and water quality.

Science and Technology
Small businesses
Catalytic Application Testing For Accelerated Learning Chemistries Via High-Throughput Experimentation And Modeling Efficiently Sbir/STTR (Catalchem-E Sbir/STTR)
$3,500,000
US Department of Energy (Advanced Research Projects Agency Energy )
Federal

Application Deadline

Dec 17, 2024

Date Added

Nov 15, 2024

This grant provides funding to small businesses to accelerate the development of advanced catalytic technologies that support the transition to sustainable energy and reduce carbon emissions.

Opportunity Zone Benefits
Small businesses
NeuroNEXT Small Business Innovation in Clinical Trials (U44 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Nov 13, 2024

This funding opportunity provides financial support to small businesses in the U.S. for conducting exploratory clinical trials or biomarker validation studies aimed at advancing therapies for neurological disorders.

Health
Small businesses
Disruptive DC Converters For Grid Resilient Infrastructure To Deliver Sustainable Energy Sbir/STTR (Dc-Grids Sbir/STTR)
$4,505,859
US Department of Energy (Advanced Research Projects Agency Energy )
Federal

Application Deadline

Mar 3, 2025

Date Added

Nov 8, 2024

This funding opportunity provides financial support for small businesses and research institutions in the U.S. to develop innovative high-voltage direct current technologies that improve grid resilience and facilitate the integration of renewable energy sources.

Opportunity Zone Benefits
Small businesses
Addressing Challenges in Detecting New Drugs: Instrumentation for Alternative Analytical Methods (R43/R44 - Clinical Trials Optional)
$3,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 19, 2025

Date Added

Nov 5, 2024

This funding opportunity is designed for small businesses to develop affordable and innovative devices that can quickly and accurately detect both known and unknown drugs in biological samples, particularly in resource-limited settings like emergency departments and health centers.

Education
Small businesses
Addressing Challenges in Detecting New Drugs: Instrumentation for Alternative Analytical Methods (R41/R42 - Clinical Trials Optional)
$3,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 19, 2025

Date Added

Nov 5, 2024

This funding opportunity is designed for U.S.-based small businesses to develop innovative, cost-effective drug detection devices that can quickly identify both known and new drugs without relying on traditional antibody-based methods.

Education
Small businesses
FY 2025 NIST Small Business Innovation Research Program Phase I
$100,000
U.S. Department of Commerce (National Institute of Standards and Technology)
Federal

Application Deadline

Dec 27, 2024

Date Added

Oct 30, 2024

This grant provides funding to small businesses for innovative research projects that can be commercialized, particularly those addressing federal agencies' research needs and promoting participation from underrepresented groups.

Science and Technology
Small businesses
Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial NOT Allowed)
$55,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Oct 29, 2024

This funding opportunity provides financial support to small businesses with active Phase I SBIR or STTR grants from NIH or CDC, helping them accelerate the commercialization of biomedical and public health innovations through training and market research.

Education
Small businesses
Rural Energy for America Program 2025
$1,000,000
U.S. Department of Agriculture (Rural Business-Cooperative Service )
Federal

Application Deadline

Mar 31, 2025

Date Added

Oct 25, 2024

This program provides financial assistance to rural small businesses and agricultural producers for renewable energy projects and energy efficiency improvements to help reduce energy costs and promote sustainability.

Energy
Small businesses
DOE Industrial Training & Assessment Centers (ITAC) Implementation Grants
$300,000
U.S. Department of Energy
Federal
Rolling

Application Deadline

Not specified

Date Added

Oct 3, 2024

This program provides funding to small and medium-sized manufacturing companies and water/wastewater treatment facilities to implement energy efficiency improvements and reduce emissions, while also creating job opportunities in disadvantaged communities.

Energy
Small businesses